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Old 11-19-2007, 08:47 AM
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Doc_Ammara
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Posts: 173
Join Date: May 2006
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Location: Multan, Pakistan
   
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Exactly. you have guessed it very right. let me add a bit more to it. actually, both Quinidine and Procainamide are Class 1A anti-dysrrythmic drugs. their main cardiac effect is depressant via blockage of Na channels and all that you know. besides that, both drugs have mild intrinsic anti-muscarinic effects(mainly increased SA nodal rate and increased heart rate),this definitely counter-acts their primary depressant effect,so the drug that has lesser anti-muscarinic effect will be more efficacious in manifesting its primary anti-depressant effect i.e Procainamide. okay. thats it!
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